消痰散结方对荷S180肉瘤小鼠蛋白质代谢的影响

doi:10.3971/j.issn.1000-8578.2010.05.010

消痰散结方对荷S180肉瘤小鼠蛋白质代谢的影响

Effect of Xiaotansanjie Recipe on Protein Metabolic of S180 Bearing Mice

摘要

摘要: 目的运用荷S180小鼠模型，观察消痰散结方改善肿瘤蛋白质代谢状况的作用，探索其作用机制。方法将40只小鼠随机分为消痰散结方组（A组）、化疗（喃氟啶）组（B组）、0.9%氯化钠溶液组（C组），对照组（D组），前三组进行S180肉瘤皮下接种造模；4周后，观察各组体重，血清生化检测总蛋白、白蛋白和C-反应蛋白（CRP）水平，免疫组化观察骨骼肌结构及骨骼肌NF-κB 的表达。结果消痰散结方可升高荷瘤鼠血清总蛋白、白蛋白水平，下调血清CRP水平，对骨骼肌结构具有保护作用。结论消痰散结方可以改善肿瘤蛋白代谢状况，其可能途径是通过调节肝脏的蛋白代谢。

Abstract: Objective To investigate the effects of Xiaotansanjie Recipe on protein metabolic of S180 bearing mice and discuss its mechanism. Methods Forty mice were randomly divided into 4 groups: XiaotanSanjie Recipe group(A group);FT-207 group (B group); NS group(C group); normal group. The mice were sacrificed on the 4th week. The weights of mice were measured. Total protein, albumin and CRP of blood were detected . The expression of muscle NF-κB was analyzed by immunohistochemistry． Results Xiaotansanjie Recipe can up-regulate total protein and albumin of blood, down-regulate blood CRP in mice. It also can protect the structure of the muscle. Conclusion Xiaotansanjie Recipe adjusted the protein metabolic abnormalities in tumor-bearing mice．It might be one of the mechanism responsible for its anti-tumor effects.

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