Abstract: Objective To study the expression of OPN and VEGF in breast cancer and to explore the effect of OPN and their unions recurrent and metastatic breast cancer. Methods Forty cases with recurrence or metastasis in 5 years (group A)，30 cases without recurrence or metastasis in 5 years (group B),and 10 cases with breast fibroid tumor（group C）and 15 cases normal breast tissue (group D), surgically resected in the department of breast surgery, Xiang ya hospital, from 1996 to 2001, were included in this study. The expressions of OPN and VEGF were studied in four groups with immunohistochemical staining technique. Results (1)The positive expression rate of OPN in breast cancer was 72.86%，which was different from group C and group D (P<0.001).(2)The expressions of OPN and their unions were statistically significant different between group A and B.(3)The expression of OPN and VEGF was direct correlation (P<0.05，r＝0.421). Conclusion The positive expression rates of OPN may correlate with the development and prognosis of breast carcinoma. Its expression was positively correlated with VEGF. The patients with OPN and VEGF union expression had the worse prognosis.