蛇葡萄素对人胃癌细胞SGC-7901裸鼠移植瘤生长的抑制作用

doi:10.3971/j.issn.1000-8578.2010.03.011

蛇葡萄素对人胃癌细胞SGC-7901裸鼠移植瘤生长的抑制作用

Anti-tumor Effects of Ampelopsin on Human Gastric Cancer SGC-7901 Implanted in Nude Mice

摘要

摘要: 目的观察蛇葡萄素(APS)体内抗人胃癌作用。方法采用人胃癌细胞裸鼠移植瘤模型，将裸鼠随机分成5组，APS三个剂量连续灌胃给药10天，观察肿瘤体积、相对肿瘤体积(RTV)、相对肿瘤增殖率（T/C）、瘤重、抑瘤率(IR)，以此评价APS的抗肿瘤作用。结果在人胃癌细胞株SGC-7901裸鼠移植瘤的抑瘤实验APS 600mg/kg、300mg/kg、150mg/kg灌胃给药10天，其相对肿瘤增殖率为52.84%、71.12%、62.14%，其抑瘤率分别为38.8%、27.5%、27.3%。结论 APS对人胃癌细胞株SGC-7901裸鼠移植瘤有明显的抑制作用。

Abstract: Objective To investigate the effects of ampelopsin(APS) on the growth of human gastric cancer cell SGC-7901 in nude mice. Methods SGC-7901 cells were inoculated into the nude mice to establish gastric cancer model.Then the BALB/C nude mice with xenograft tumor were randomized into 5 groups.The ampelopsin was administered at 3 dosages by irrigate the stomach daily for 10 d.The anti-tumor effects of ampelopsin was evaluated based on the tumor volume，relative tumor volume(RTV)，tumor weight，relative tumor proliferative rate （T/C）and tumor inhibition rate(IR). ResultsAt the 600mg/kg,300mg/kg,150mg/kg dose of APS,the relative tumor proliferation rate was 52.84％,71.12％ and 62.14%,respectively,and the growth inhibition of the transplanted tumor was 38.8％,27.5% and 27.3%,respectively. Conclusion APS in appears to be a potent anti-tumor agent that was firstly discovered in the transplanted human gastric cancer cell SGC-7901 in nude mice in vivo.

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