诺维本、吡喃阿霉素联合治疗晚期乳腺癌

NVB and THP Combination Chemotherapy in the Treatment of Advanced Breast Cancer

摘要: 目的　观察诺维本 (NVB) +吡喃阿霉素 (THP)联合治疗晚期乳腺癌疗效。方法　NVB+THP联合治疗 31例晚期乳腺癌, 均为女性, 其中Ⅲ期 18例, Ⅳ期 13例。结果　本组 31例完全缓解 (CR) 3例, 部分缓解 (PR) 16例, 有效率为 61 3%。主要毒付反应, 是骨髓抑制或静脉炎, 白细胞下降为 93 2 %,其中Ⅲ、Ⅳ度为 50 2 %,静脉炎发生率为 4 2 0 %。结论　NVB +THP联合治疗乳腺癌, 有效率较高, 但骨髓抑制发生率高, 必须引起重视。

Abstract: Objective To evaluate the combined chemotherapy efficacy and toxicity of NVB and THP on advanced breast cancer. Methods All the 31 patients were treated with NT regimen NVB 25mg/M2 iv for Day 1 and 8;THP 45mg/m2 iv for Day 1. Results Complete response was 3 cases,Partial response 16 cases,the overall response rate was 61.3%. Side reactions were mainly myelosuppression and phlebitis. Conclusion The NT regimen is a better chemotherapy regimen for advanced breast cancer.