Abstract: Objective The objective of this study is to discuss the independent prognostic factors in the patients of smallcell lung cancer(SCLC). Methods One hundred and twenty-three patients of SCLC were reviewed. The potential prognostic factors such as: gender, age，smoke，complication，clinical stage， ECOG performance status，treatment，CEA，chemotherapy induced leucopenia(CIL) were analyzed by Cox regression using SPSS15.0 software. Results After 1 to 52 months follow-up,103 patients died. The surival rate in 6 month, 1st year, 2nd year, 3rd year and 4th year were 70.7%，34.1%，8.94%，2.4%and 0.8%，respectively. Median survival time(MST) was 11 months95%CI(9.328, 12.627).Cox regression showed that the independent prognostic factors on the surival time were ECOG performance status (P=0.000), chemoradiotherapy (P=0.000), clinical stage (P=0.024), and CIL (P=0.013). Conclusion Patients of SCLC, who are in limited clinic stage,with low ECOG performance status,have been treated with chemoradiotherapy and showed CIL, will prolong the survival time (P<0.05) and have a better life quality.