MUC1蛋白在胆囊癌中的表达及其意义

doi:10.3971/j.issn.1000-8578.2009.10.009

MUC1蛋白在胆囊癌中的表达及其意义

Expression and Significance of MUC1 in Gallbladder Carcinoma

摘要

摘要: 目的 MUC1在胆囊癌组织中的表达及临床病理意义。方法采用免疫组织化学PV6000二步法检测MUC1在胆囊癌及癌旁组织中的表达情况，并结合临床病理资料进行分析。结果 MUC1蛋白在胆囊癌组织表达率为51.7% (31/60)，而在癌旁非癌组织中未见有阳性表达，两者表达差异具有统计学意义(P=0.000)。MUC1表达与胆囊癌分化程度相关，高分化组与低分化组之间在MUC1表达上差异有统计学意义(P<0.05)，而与其他临床参数及预后无关(P>0.05)。结论 MUC1在胆囊癌组织中阳性表达率增高,可能与胆囊癌发生发展有

Abstract: Objective To investigate the expression of MUC1 in gallbladder carcinomas and its clinicopathological significance. Methods Expression of MUC1 was detected by PV6000 immunohistochemical method in gallbladder carcinomas and normal mucosa beside the carcinomas. Results All normal mucosa beside the carcinomas were negative for MUC1. In the 60 cases of gallbladder carcinomas, positive rate of MUC1 was 51.7% .The expressions of MUC1 in gallbladder carcinomas was significantly higher than that in normal mucosa beside the carcinomas (P<0.05) . No significant correlation was found between the expression of MUC1 and other clinical pathological data and prognosis. Conclusion There was a higher positive rate of MUC1 in gallbladder carcinomas, which indicated that MUC1 may play an important role in the development of the tumor.

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