Abstract: Objective To analysis the effect of hyperfractionated three-dimensional conformal radiotherapy (HF-3DCRT) combined with transarterial chemoembolization (TACE) for advanced liver carcinoma. Methods Total of 45 patients with unresectable advanced liver carcinoma were randomly devided into two groups: 22 patients were treated with HF-3DCRT plus TACE and the rest 23 patients were treated with TACE alone. TACE were treated with 2 sessions in either group. For HF-3DCRT, radiation was provided by 6MV X ray, patients received a total dose of 45~55Gy(3~5Gy per session) every other day. Results The survival rates of HF-3DCRT plus TACE group in the 1st, 2ed and 3rd year were 68.7%, 56.8%and 39.8%; 51.2%, 28.7% and 15.7%, respectively, in the TACE group. The difference between the two groups was significant. The response rates (CR+PR) of HF-3DCRT plus TACE group and TACE alone group were 85.7% and 52.3%, the difference was statistically significant difference. There was no difference of side-effect between the two groups (P>0.05). Conclusion Hyperfractionated three-dimensional conformal radiotherapy plus transarterial chemoembolizaton is effective for the treatment of advanced liver carcinoma and the patients can tolerate the side-effects.