Abstract: Objective To evaluate the efficacy and toxicity of TACE using Irinotecan and lipiodol combining with intravenous CF/5-Fu in the treatment of hepatic metastasis from colorectal cancer. Methods Twenty six cases with hepatic metastasis from colorectal cancer were treated by the above-mentioned method, every three weeks was a cycle. Results Two cases had complete response, eight cases had partial response,thirteen cases had stable disease and three cases with progressive disease. Gross efficiency rate was 38.46% and the stability rate was 50%.The clinical beneficial response rate was 88.46%.Median time to progression was 7.3 months and median overall survival time was 14.2 months. The common treatment related adverse events were neutropenia and delayed diarrhea. Toxic effect was light. Conclusion TACE using Irinotecan and Lipiodol combining with intravenous CF/5-Fu in the treatment of hepatic metastasis from colorectal cancer is an effective and well tolerated regimen.