Abstract: Objective To investigate the expression of c-erbB-2, ER, PR and their prognostic relationship premenopausal and postmenopausal patients with breast cancer. Methods The pathological data of 432 patients with primary breast cancer were analyzed retrospectively. One hundred and ninety-five patents were followed up for 5 years. The expression of c-erbB-2, estrogen receptor(ER) and progesterone receptor(PR) in cancer specimens of 432 patients were detected by immunohistochemistry in. Results (1) In premenopausal patients, the positive rate of ER expression in patients with positive expression of c-erbB-2 was significantly lower than that in patients with negative expression of c-erbB-2(P=0.003). In postmenopausal patients, the positive rate of ER and PR expression in patients with positive expression of c-erbB-2 were significantly lower than those in patients with negative expression of c-erbB-2(P＜0.001,P=0.005).(2)The Cox multivariate analysis showed that c-erbB-2 expression and lymph node metastasis were independent prognostic factors in premenopausal patients, and that c-erbB-2 expression, lymph node metastasis and ER expression were independent prognostic factors in postmenopausal patients. Conclusion The clinical implications of c-erbB-2, ER and PR are different between premenopausal and postmenopausal patients with breast cancer.