139例急性髓系白血病免疫分型特点分析

doi:10.3971/j.issn.1000-8578.2009.03.019

139例急性髓系白血病免疫分型特点分析

Characteristic Analysis of Immunological Classification of 139 Examples Acute Myeloid Leukemia

摘要

摘要: 目的探讨急性髓性白血病（AML）的免疫分型特点及意义。方法采用单克隆抗体和流式细胞仪检测AML的免疫表型。结果（1）139例AML病例中各种抗原的阳性表达率依次为为MPO（92.1%），CD33（92.1%），CD13(89.2%),其中53例AML伴淋巴系抗原表达,分别为CD19(20.9%),CD7(16.2%),CD2(7.2%),CD10(0.72%)。(2)CD14在M4、M5型AML中高表达。(3)干祖细胞分化抗原表达率依次为CD117（83.8%）〉HLA-DR(80.3%)>CD34(67.6%),CD34阳性的完全缓解率（CR）分别明显低于CD34阴性组（P=0.034）。（4）CD7阳性患者CR明显低于其抗原表达阴性者（P=0.041）。结论白血病免疫分型能确诊某些特殊类型的白血病，对免疫分型的研究将有助于指导临床诊断、治疗及判断预后。

Abstract: To study the characteristics of antigen expression and its clinical significance in acute myeloid leukaemia (AML). Methods The immunological phenotypes in patients with AML were assayed using monoclonal antibodies by flow cytometry. Results (1)In 139 cases, the ratio of antigen expression was MPO 92.1%, CD33 92.1% and CD13 89.2 %；respectively. Meanwhile 53 cases accompanying lymphocyto antigen expression，the ratio was CD19 20.9%, CD7 16.2%,CD2 7.2% and CD10 0.72%， respectively.(2)CD14 was highly expressed in M4、 M5 subtype. (3)The positive rate of stem or progenitor cell differentiation antigens CD117（83.8%）， HLA-DR(80.3%)，CD34(67.6), respectively.CR of the CD34 positive patients was significantly lower than CD34 negative ones (P =0.034).(4）CR of the CD7 positive patients was significantly lower than that of CD7 negative ones(P=0.041) . Conclusion Leukemia immunophenotyping could classify some particular types of myeloid leukemia and is important in diagnosis,treatment and prognositic criterion of AML.

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