食管癌血管形成相关因子的表达及意义

doi:10.3971/j.issn.1000-8578.2001.03.012

食管癌血管形成相关因子的表达及意义

Expression of Transcription Factor Correlated with Angiogenesis and Their Clinical Significance in Esophageal Carcinoma

摘要

摘要: 目的探讨不同组织类型食管癌中NF-κB、VEGF-C、MVD的表达及与临床特征的关系。方法采用免疫组织化学二步法检测47例食管鳞癌、41例食管腺癌及34例食管小细胞癌中NF-κB、VEGF-C的表达情况，并对微血管密度（MVD）进行计数。采用RT-PCR检测50例食管癌及20例正常食管组织相关基因。结果NF-κB在食管鳞癌、腺癌和小细胞癌的阳性表达率分别为59.57%、36.59%和67.65%(P＜0.05)；VEGF-C 在食管鳞癌、腺癌和小细胞癌阳性表达率为65.96%、85.37%和79.41%(P＞0.05)。结论VEGF-C和NF-κB在食管癌发生发展中起着一定的作用，VEGF-C在食管腺癌中表达较高，NF-κB食管小细胞癌中表达较高。MVD在三者之间无差异。食管鳞癌、腺癌和小细胞癌形成微血管的机制可能稍有不同，深入研究其具体的形成机制，可为临床提供针对性的治疗方案。

Abstract: ObjectiveTo investigate the expression of NF-κB、VEGF-C、MVD and their relationships with esophageal carcinoma of different constitution. MethodsEnvision immunohistochemical method was used to detect the expression of NF-κB,VEGF-C and MVD in 47 cases of squamous cell esophageal carcinoma ，41 cases of the adenocarcinoma of esophagus and 34 cases of the small cell carcinoma of the esophagus. ResultsNF-κB positive rate was 59.57% in squamous cell carcinoma of esophagus,and in adenocarcinoma of esophagus and small cell carcinoma of the esophagus,the rates were 36.59% and 67.65%(P＜0.05),respectively. The positive rates of VEGF-C were 65.96%、85.37%、79.41% (P＞0.05),respectively. ConclusionThe positive rate of VEGF-C in adenocarcinoma of esophagus was higher than that in squamous cell carcinoma of esophagus and small cell carcinoma of the esophagus.But the NF-κB positive rate was the highest in small cell carcinoma of the esophagus.MVD results showed no difference due to possible different mechanism of angiogenesis. Further investigation will be necessary in order to understand the concrete mechanism.

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