藓化饮对口腔黏膜癌前病变的逆转作用

doi:10.3971/j.issn.1000-8578.1925

藓化饮对口腔黏膜癌前病变的逆转作用

Reversal Action of XianHuaYin on Premal ignant Lesion of Oral Mucosa

摘要

摘要: 目的　探讨检测口腔扁平苔藓(OL P) 癌变高危相的指标及藓化饮对OL P 癌前病变的逆转作用。方法　对36 例OL P 患者、32 例正常人和30 例癌症病人进行口腔黏膜脱落细胞微核率、唾液中α2 羟丁酸脱氢酶(α2HBDH) 含量、外周血免疫功能和端粒酶标记率检测;并对OL P 患者采用藓化饮治疗, 观察治疗前后的效果。结果　OL P 患者组脱落细胞微核率、唾液α2HBDH 含量、外周血端粒酶标记率均高于正常对照组,而与癌症对照组无明显差异。OL P 患者组经用藓化饮治疗后三项指标均明显降低,患者免疫功能状态明显改善。结论　脱落细胞微核率、唾液α2HBDH 含量、外周血端粒酶标记率在反映OL P 患者病情变化和OL P 高危相方面可能有意义,藓化饮对OL P 癌前病变具有逆转作用。

Abstract: Objective 　To detect indicat rix high risk of canceration of OL P and the reversal action of pre2 cancerous lesion of OL P with XianHua Yin. Methods 　Micronucleus rate of oral mucosal exfoliated cells, α2HBDH content in saliva, and labelled rate of telomere enzyme in peripheral blood were detected in 36 OL P patient s of t reatmenting before and af ter with XianHuaYin, 32 normal people and 30 cancer pa2 tient s. Results 　Micronucleus rate of oral mucosal exfoliated cells, α2HBDH content in saliva, and labelled rate of telomere enzyme in peripheral blood in OL P patient s were higher than those of normal cont rol group . There were obviously no difference to compare cancer patient s. These indicat rixs of 36 OL P obvi2 ously declined af ter t reatment . Immune function of patient s obviously is improved. Conclusion 　Micronu2 cleus rate of oral mucosal exfoliated cells, α2HBDH content in saliva, immune functional status and la2 belled rate of telomere enzyme in peripheral blood may reflect their changes of OL P and may be of signifi2 cance on monitoring the high risk phase of OL P. XianHuaYin could reverse the lesion precancerous of OL P.

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