Abstract: Objective 　To investigate the clinicopathological significance of the lymphatic microvessel den2 sity (LMVD) in primary gast ric adenocarcinoma. Methods 　Monoclonal antibody D2240 was used immu2 nohistochemically to detect the lymphatic microvessel density(LMVD) in the int ra2 and peri2tumoral areas of the primary gast ric adenocarcinoma and normal gast ric tissue, and analysis the relationship among the lymphatic microvessel density (LMVD), lymphatic invasion, lymph node metastasis and other clinico2 pathological parameters of the primary gast ric adenocarcinoma. Results 　LMVD of the peri2tumoral area was significantly higher than that of int ra2tumoral area and nomal tissue ( P < 0. 05) . LMVD of the peri2 tumoral area was significantly associated with Ming Classification, lymphatic invasion and lymph node metastasis ( P < 0. 05), while less associated with age, sex, differentiation and invasion of the tumor ( P >0. 05) . LMVD of the int ra2tumoral area was not correlated with these clinicopathological parameters ( P >0. 05) . Conclusion 　LMVD of the peri2tumoral area was significantly associated with lymphatic invasion and lymph node metastasis, and detection of LMVD in peri2tumoral area can be used for prediction of lymph node metastasis.