Abstract: Objective 　To investigate the expression of Ezrin and CD44 and their correlations with clinical2 pathological parameters in gast ric carcinoma. Methods 　The expression of Ezrin and CD44 in 50 speci2 mens of gast ric carcinoma, 25 specimens of gast ric epithelial dysplasia and 25 specimens of normal gast ric tissues were detected by immunohistochemist ry method. Results 　①In normal gast ric tissues, gast ric dysplasia and gast ric carcinoma, the percentage of Ezrin positive expression was 28. 0 %, 36. 0 % and 86. 0 %, respectively, the percentage of CD44 expression was 0, 16. 0 % and 60. 0 %. The expression of Ezrin and CD44 increased gradually in normal gast ric tissues, gast ric dysplasia and gast ric carcinoma. The difference has a statiftical significance ( P < 0. 05) . ②The expression of both Ezrin and CD44 was correlated to clinical stage, metastasis of lymph node, and there were substantial differences ( P < 0. 01), but theses were not correlated to carcinoma differentiation ( P > 0. 05) . ③ The expression of Ezrin was positively correlated to that of CD44 in gast ric carcinoma ( P < 0. 01) . Conclusion 　The expression of Ezrin and CD44 was correlated to clinical stage and metastasis of lymph node. Joint examination of these two parameters is useful for forecast metastasis and prognosis of gast ric carcinoma.