Podoplanin和血管内皮生长因子-C在结肠癌中的表达及与淋巴结转移的关系

The Expression of Podoplanin/VEGF-C and Lymph Node Metastasis in Human Colon Carcinoma

摘要: 目的探讨结肠癌组织中Podoplanin、血管内皮生长因子C(VEGFC)表达的相互关系及其在淋巴结转移过程中的作用和可能机制。方法应用免疫组化法检测48例结肠癌组织和10例癌旁组织中Podoplanin及VEGFC的表达水平。结果(1)结肠癌组织中Podoplanin、VEGFC阳性表达率分别为56.3%、64.6%,显著高于癌旁非癌组织的10%(P<0.05)。(2)Podoplanin、VEGFC的表达与结肠癌的浸润深度、淋巴结转移及TNM分期相关(P<0.01或P<0.05),与结肠癌的分化程度、远处转移无关(P>0.05)。(3)Podoplanin、VEGFC之间表达呈正相关(r=0.425,P<0.01)。结论结肠癌组织中Podoplanin、VEGFC表达均增高且呈正相关,两者在结肠癌淋巴结转移中有协同效应,共同促进结肠癌的淋巴转移

Abstract: Objective This study was designed to investigate the relationship between Podoplanin and VEGF-C in human colon carcinomas and discuss the significance of Podoplanin、VEGF-C in lymph mode metastasis. Methods The expression of Podoplanin and VEGF-C in forty-eight colon carcinoma tissues and ten adjacent noncancerous specimens was evaluated by immunohistochemical analysis. Results (1) Podoplanin was overexpressed in 27 of 48 carcinoma tissues ( 56.3%) and VEGF-C was overexpressed in 31 of 48 ( 64.6%),which were s...