Abstract: Objective 　To evaluate the state of the peripancreatic vessel encroached by pancreatic carcinoma using multi-slice CT angiography (CTA) on epigast rium, and discuss the significance of CTA. Methods 　Patients with pancreatic carcinoma were scanned by Toshiba Aquilion 16-detector row computed tomography (CT) . CT angiography in arterial phase and portal phase of the major peripancreatic vessel were mapped. The state of the peripancreatic vessel encroached by pancreatic carcinoma were distinguish and evaluate both in three-dimension and purely axis images, and were compared with the state seen in operation. Results 　Forty-two patients underwent operation. Twenty-eight cases with major peripancreatic vessel invaded were affirmed with CTA. In them, twenty-five cases were affirmed with purely axis images. Twenty-nine cases with major peripancreatic vessel invaded were affirmed in the operation. For display of peripancreatic vessel invaded with CTA, the sensitivity was 96. 43 %, and the specificity was 92. 31 %. For display of peripancreatic vessel invaded with purely axis images, the sensitivity was 82. 76 %, and the specificity was 92. 31 %. Conclusion 　Compared with axis CT images, the prediction of peripancreatic vessel invaded with CTA was significant in prospective guide for surgery.