人绒毛膜促性腺激素在大肠病变中表达的研究

Study of the Expression of Human Chorionic Gonadotropin in Colorectal Diseases

摘要: 目的　探讨HCGα、β亚基在大肠病变中的表达及其临床病理意义。方法　采用免疫组织化学链霉卵白素过氧化物酶复合物法(SP法)检测大肠病变中HCG不同亚基的表达。结果　HCGα在大肠良性病变中存在表达，在恶性病变中未见表达；HCGβ在良性病变中罕见表达，在大肠癌中表达较高。结论　HCG的不同亚基的大肠良恶性病变中的表达有所不同。HCGβ的表达与大肠癌的分化及分期有关，可以作为大肠癌恶性分化的一种参考指标。

Abstract: Objective To study the expression and significance of HCG subunits in the colorectal diseases. Methods Streptavidin peroxidase immunohistochemical methods was used to detect the expression of HCG subunits. Results HCGα immunohistochemical positive cells only expressed in benign colorectal disease;The positive cells of HCGβ was rare in benign colorectal disease.Where as the expression rate of HCGβ was higher in colorectal carcinoma. Conclusion The distribution of the HCG subunits was different in the benign and malignant colorectal diseases.The expression of HCG β was associated with the differentiation and stage of the colorectal carcinoma,and its expression may be a reference to the malignance differentiation of the colorectal carcinoma.