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外放射对鼻咽鳞癌P 糖蛋白的影响

刘 宇, 张幸平, 陈鸿雁, 邓红彬, 徐 曼, 李圆圆

刘 宇, 张幸平, 陈鸿雁, 邓红彬, 徐 曼, 李圆圆. 外放射对鼻咽鳞癌P 糖蛋白的影响[J]. 肿瘤防治研究, 2005, 32(08): 470-472. DOI: 10.3971/j.issn.1000-8578.1609
引用本文: 刘 宇, 张幸平, 陈鸿雁, 邓红彬, 徐 曼, 李圆圆. 外放射对鼻咽鳞癌P 糖蛋白的影响[J]. 肿瘤防治研究, 2005, 32(08): 470-472. DOI: 10.3971/j.issn.1000-8578.1609
LIU Yu, ZHANG Xing-ping, CHEN Hong-yan, DENG Hong-bin, XU Man, LI Yuan-yuan. Effect of Radiation on p-glycoprotein Expression in Nasopharyngeal Squamous Carcinoma[J]. Cancer Research on Prevention and Treatment, 2005, 32(08): 470-472. DOI: 10.3971/j.issn.1000-8578.1609
Citation: LIU Yu, ZHANG Xing-ping, CHEN Hong-yan, DENG Hong-bin, XU Man, LI Yuan-yuan. Effect of Radiation on p-glycoprotein Expression in Nasopharyngeal Squamous Carcinoma[J]. Cancer Research on Prevention and Treatment, 2005, 32(08): 470-472. DOI: 10.3971/j.issn.1000-8578.1609

外放射对鼻咽鳞癌P 糖蛋白的影响

详细信息
    通讯作者:

    刘 宇

  • 中图分类号: R739. 63 ;R730. 55

Effect of Radiation on p-glycoprotein Expression in Nasopharyngeal Squamous Carcinoma

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    Corresponding author:

    LIU Yu

  • 摘要: 目的 初步探讨放射治疗前、后鼻咽鳞癌组织P-糖蛋白(P-gp)的表达及变化特点。方法 应用免疫组织化学SP法检测了48例初治鼻咽鳞癌患者放射治疗前、后P-gp的表达。结果 48例初治鼻咽鳞癌组织P-gp阳性表达率放射治疗前为18.75%(9例/48例),其中低分化鳞癌和中高分化鳞癌分别为17.65%(6例/34例)和21.43%(3例/14例);放射治疗后P-gp阳性表达率为75.00%(36例/48例),其中低分化鳞癌和中高分化鳞癌分别为79.41%(27例/34例)和64.29%(9例/14例)。放射治疗后P-gp阳性表达率较放射治疗前呈增高趋势,放射治疗后P-gp阳性率和放射治疗前相比有显著性差异(P〈0.001)。结论 放射治疗可诱导和加强鼻咽鳞癌组织中P-gp表达,这可能是引起放、化疗交叉耐药的原因之一。

     

    Abstract: Objective  To investigate preliminarily the expression of p-glycoprotein ( P-gp) in patients with nasopharyngeal squamous carcinoma (NPSC) pre- and post-radiotherapy. Methods  The immunohistochemistry with one monoclonal antibody JSB-1 staining was performed to test the expression of pgp in pre- and post-radiotherapy NPSC specimens from 48 patients . Results  The positive rate of P-gp expression in the patients with NPSC pre-radiotherapy was 18. 75 %(9/ 48) . Among them, the positive expression rate was 17. 65 %(6/ 34) and 21. 43 %(3/ 14) in low grade differentiation squamous cell carcinoma and mid-high grade differentiation squamous cell carcinoma, respectively. The positive expression rate of post-radiotherapy was 75. 00 %(36/ 48) and among them, the positive expression rate was 79. 41 %(27/34) 、64. 29 %(9/ 14) in low grade differentiation squamous cell carcinoma and mid2high grade differentiation squamous cell carcinoma, respectively. P-gp expression rate post-radiotherapy was significantly higher than that of pre-radiotherapy ( P < 0. 001) . Conclusion  Our study indicates that pgp expression in NPSC was significantly induced by radiation and increases the overexpression of P-gp. Therefore, irradiation may be one of the reasons of crossed resistance to chemotherapy and radiotherapy.

     

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出版历程
  • 收稿日期:  2004-10-07
  • 修回日期:  2005-04-26
  • 刊出日期:  2005-08-04

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