Abstract: Objective 　To investigate the clinical curative effects and side effects of chemoradiotherapy for medium-term and advanced cervical carcinoma. Methods 　Fifty-eight patients of medium-term and advanced cervical carcinoma were randomly divided into two groups : chemoradiotherapy group s and only radiotherapy group. Each patient s of the chemoradiotherapy group was given cisplatin at the dose of 25mg/ m² ivgtt d1-3, 5-Fluorouracil, 350mg/ m² ivgtt, d1-5, repeat every 28 days, total 3 cycles. And radiotherapy was give at the same time, 10 MVX ray was used for external radiation with a total dose of 38～40 Gy ;then the middle field is shielded by plumbum, continuous radiotherapy to total dose of 50～55 Gy ;192 Irhigh-dose-rate af ter loading unit was used for branchytherapy after 3 weeks of external radiotherapy at the dose in A point of 6 Gy per time for total 6～7 times. The patients of radiotherapy group were only received radiotherapy with the same dose and same methods. Results 　The effect rates of the chemoradiotherapy group and radiotherapy group were 96. 6 % and 86. 2 % respectively at the end of the radiotherapy with no difference significantly ( P > 0. 05) ; Three months after radiotherapy the effect rates in both groups were 96. 6 % and 65. 5 %, showing a significant difference ( P < 0. 05) . The overall 32year, 52year survival rates for the patients in chemoradiotherapy group and radiotherapy group were 79. 3 %, 68. 9 % and 62. 1 %, 51. 7 % respectively, P < 0. 05. Disease-free survival rates were 62. 1 % and 41. 4 % respec-tively, P < 0. 05. Pelvic recurrence rates were 31. 0 % and 17. 2 % respectively P < 0. 05. More serious side effects were found in the chemoradiotherapy group. Especially in bone marrow inhibition and reaction of digestive tract, Which could be alleviated. Conclusion 　Concurrent chemotherapy and radiotherapy in medium-term and advanced cervical carcinoma can increase t reatment effect and raise the survival of the patients, obviously improve the short-term curative effect . Toxicity of patients was increasing but the patients could tolerate.