P-gp 、GST-Л、p53 和CD44v6 在肺癌中的表达

doi:10.3971/j.issn.1000-8578.1530

P-gp 、GST-Л、p53 和CD44v6 在肺癌中的表达

The Expression and Clinical Significance of P-gp、GST2Л、p53 and CD44v6 Gene Protein in Lung Cancer

摘要

摘要: 目的探讨多药耐药基因（MDR）产物P-糖蛋白（P-gp）、谷胱甘肽-S-转移酶π（GST-π）及p53、CD44V6在肺癌组织中的表达及其相互关系。方法采用免疫组化SP方法检测60例肺癌组织中p-gP、GST-π和p53、CD44v6的表达情况。结果①肺癌组织中P-gp、GST-π阳性表达率分别为63．3％、66．7％。GST-π和P-gp在非小细胞肺癌（NSCLC）中的表达率分别为69．8％和73．6％，在小细胞肺癌（SCLC）的阳性表达率均为14．3％，两者比较均有显著性差异（P〈0．05，P〈0．01）。GST-π和P-gp在肺腺癌中的表达明显高于肺鳞癌和小细胞癌组（P〈0．05，P〈0．01）②CD44v6在肺癌的阳性表达率为65．0％，在有淋巴结转移组的表达明显高于无淋巴结转移组（P〈0．05）。③P-gp和GST-π在肺癌中的共表达率为41．7％，P-gp表达和GST-π表达呈正相关性（P〈0．05）。P-gp和p53在肺癌中的共表达率为48．3％，P-gp表达和p53表达呈显著正相关性（P〈0．01）。结论P—gp、GST—π和p53在肺癌组织中的表达对肿瘤的耐药起重要作用，CD44v6是预测肺癌侵袭转移及估计预后的一个重要指标。

Abstract: Objective 　To explore the expression and clinical significance of P-gp 、GST-Лand p53 and CD44v6 gene protein in human lung cancer. Methods 　The expression of P-gp 、GST-Лp53 and CD44v6 protein were detected in 60 cases of lung cancer tissue with SP immunohistochemical method and analyzed. Results 　The result showed that : ① the positive expression of P-gp and GST-Лseparately were 69. 8 % and 73. 6 % in NSCLC, which were much higher than the positive expression in SCLC(14. 3 %) ( P <0.05), compared with adenocarcinoma and squamous carcinoma 、SCLC, the positive rate of P-gp and GST-Л in adenocarcinoma were higher ( P < 0. 05) . ②The positive rate of CD44v6 gene production is 65. 0 %, which has a significant positive correlation with lymph node metastasis ( P < 0. 05) . ③The coexpression rate of P-gp and GST-Л is 41. 7 %, P-gp significantly positively correlated with GST-Л. The coexpression rate of P-gp and p53 is 48. 3 %, P-gp had obviously positive correlation with p53. Conclusion 　The overexpression of P-gp 、GST-Лand p53 in human lung cancer made it important to influence tumor resistance. The over-expression of CD44v6 may be the good indicator for predicting metastasis and prognosis of lung cancer.

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