肿瘤转移相关基因在恶性肿瘤组织中的表达及其临床意义
Expression and Its Clinical Significance of Tumor Metastasis-Related Genes in Tumor Tissues
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摘要: 目的 探讨各种肿瘤转移相关基因编码蛋白在恶性肿瘤转移中的表达规律及其临床意义。方法 采用流式细胞术对 5 6例肿瘤转移和 6 1例肿瘤未转移患者瘤组织的CD4 4V5 +、CD4 4V6 +、c erbB 2 +、nm2 3+、DCC +和p16 +细胞检出率和DNA含量进行了检测和分析。结果 恶性肿瘤患者瘤组织细胞的CD4 4V5 +、CD4 4V6 +和c erbB 2 +细胞表达率均显著高于正常对照组 (P <0 .0 1或P <0 .0 5 ) ;nm2 3+,DCC +,p16 +细胞表达率则显著低于正常对照组 (P <0 .0 1或P <0 .0 5 )。肿瘤转移者、多器官转移者、DNA异倍体者、SPF增高者、Apo减低者的CD4 4V5 +、CD4 4V6 +、c erbB 2 +细胞表达率均显著高于未转移者、单器官转移者、DNA二倍体者、SPF不增高者、Apo不减低者 (P <0 .0 1或P <0 .0 5 )。而nm2 3+、DCC +、p16 +细胞的表达率与此相反。结论 肿瘤组织肿瘤转移相关基因编码蛋白表达水平的检测, 对肿瘤的恶性度、转移潜能、转移严重程度及患者预后估计有重要价值。Abstract: Objective To study the expression regularity and its significance of tumor metastasis related genes in tumor tissues of patients with malignant carcinoma. Methods The expression rates of CD44V5+,CD44V6+,c-erbB-2+,nm23+,DCC+,p16+ cells and DNA content in tumor tissues of 117 patients with malignant carcinomas were measured and analyzed by flow cytometry. Results The expression rates of CD44V5+,CD44V6+ and c-erbB-2+ cells in tumor tissues of patients with malignant carcinomas were higher than those of norma...
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