EB 病毒与非霍奇金淋巴瘤——附180 例报道

Association between Epste in-Barr Virus and no-Hodgkinp's Lymphomas

摘要: 目的　探讨 NHL与 EBV感染的相关性。方法　用 ISH方法检测 1 80例 NHL中EBV编码的 RNA( EBER1 /2 )。结果　 ( 1 ) EBER1 /2感染率为 42 .8% ( 77/1 80 ), 感染率依次为TCL64.8%、NK/T46.2 %、BCL9.5 %。其中 TCL、NK/T与 BCL相比, P≤ 0 .0 0 5 ;( 2 )结内、结外EBV感染率依次为 2 2 .2 %、5 3.8%, 有显著差异, P<0 .0 0 5 ;( 3)面中线 (鼻腔 /口咽环 ) EBER1 /2感染率 72 .4% ( 5 5 /76), 多形细胞性 EBER1 /2感染率 70 .1 % ( 5 4 /77)。结论　本地区 NHL与 EBV感染关系密切, TCL、NK/T淋巴瘤感染率明显高于 BCL,而且有部位限制性和亚型倾向性.

Abstract: Objective To explore the relationship between NHL and EBV. Methods In 180 cases of NHL,the presence of EBV encoded small RNA(EBER1/2) was detected by ISH. Results (1)EBER1/2 positivity was found in 77 of 180(42.8%) NHLs, including 64.8% of TCLs,46.2% of NK/T cell lymphomas and 9.5% of BCLs.The positive rates of EBER1/2 in TCLs and NK/T cell lymphomas were significantly higher than that in BCLs ( P <0.005);(2) There was a significant difference in the positive rates of EBER1/2 in intra (22.2%) and extr...