胃癌术后腹腔缓释化疗的临床研究

doi:10.3971/j.issn.1000-8578.1299

胃癌术后腹腔缓释化疗的临床研究

Clinic Study of Abdominal Postoperative Slow-released Chemotherapy on Gastric Cancer

摘要

摘要: 目的探讨缓释化疗颗粒与全身化疗联合使用对胃癌病人疗效和化疗毒副作用的影响。方法纳入36例行胃癌根治术的病人，分为单纯全身化疗组（L1l00mg／m^2＋5-Fu500mg·m^-2，1次／天，5天／周，1次／月，共6月）和联合化疗组（术中给予氟脲嘧啶缓释颗粒500-1000mg，以后每45天一次经腹腔穿刺给药共4次；术后化疗时将5-Fu减半，即：LV100mg／m^2＋5-Fu250mg·m^-2，1次／天，5天／周，1次／月，共6月）。观察各组生存率、无瘤生存率，观察记录每组病人化疗期间生存质量和化疗毒副反应。结果联合化疗组生存率及无瘤生存率均明显高于单纯全身化疗组（P〈0．01），其生活质量明显高于后者，而化疗毒副作用明显低于后者。结论缓释化疗颗粒的使用可以减少全身化疗的用药量，从而降低了全身化疗的毒副作用，提高病人生活质量，且提高了疗效。

Abstract: Objective 　To study the effect of combined slow2released fluorouracil's granule and generalized chemotherapy on survival rate and side2effect in patient s with gast ric cancer. Methods 　Thrity2six cases of radical gast rectomy were divided two groups2generalized chemotherapy group ( Ggen, LV100 mg/ m2 + 52 Fu 500 mg·m- 2 and combined chemotherapy group ( Gcom, slow2released 52Fu granule was used in opera2 tion and LV100 mg/ m2 + 52Fu 500 mg·m- 2 . Survival rate and survival rate with no tumor in both groups was analyzed. Living quality and side2effect s of during chemotherapy were observed meanwhile. Results 　Both survival rate and survival rate with no tumor were higher in Gcom than in Ggen ( P < 0. 01) . Higher living quality and lower side2effect in Gcom than those in Ggenwere observed too ( P < 0. 01 and P < 0. 05) . Conclusion 　The use of slow2released fluorouracil's granule can reduce the dose of fluorouracil used by ve2 na, then reduce the side2effect s, and rehance living quality and the t reat effect .

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