Abstract: Objective 　Chamomi Pamidronate (Bonin) with local hyperthermia t reatment of metastatic bone pain in the elderly effect . Methods 　42 elderly patient s were randomly divided into single2agent group (Bonin) 20 cases and the Joint Group (Bonin + hyperthermia) 22 ; single drug groups : 60 mg Bonin 500 ml saline infusion over four hours, repeated every 4 weeks ; Joint group : Bonin used in the same time, twice a week plus pain part s of the local hyperthermia, installed the heating temperature of 43 ℃, main2 tain constant temperature of 60 minutes, t reatment evaluation af ter two cycles ; Observation of the two groups, respectively. Results 　Group painkiller significant efficiency and complete remission rates were 91 % and 55 %. significantly higher than that of single2drug group (75 % and 45 %) . Conclusion 　Bonin with local hyperthermia t reatment of metastatic bone pain with synergies.