Fas 、FasL 在胃癌发生发展中的表达及其意义

doi:10.3971/j.issn.1000-8578.1280

Fas 、FasL 在胃癌发生发展中的表达及其意义

Expression and Significance of Fas and FasL in Human Gastric Carcinogenesis

摘要

摘要: 目的研究Fas、FasL在胃癌发生发展中的表达，并探讨其临床病理意义。方法应用免疫组化SABC法检测60例胃癌组织、癌旁交界组织、距肿瘤边缘5cm组织及20例良性胃疾病组织和20例正常胃黏膜中Fas、FasL的表达。结果胃癌组织、癌旁交界组织、距肿瘤边缘5cm组织和良性胃疾病、正常胃黏膜组织的Fas阳性表达率分别为46．6％、51．6％、83．3％、85％、95％；FasL的阳性率则分别为86．6％、81．6％、26．6％、20％、10％。在胃癌不同分化程度之间，Fas和FasL表达有显著性差异(P<0．05)。而胃癌不同TNM分期，有无淋巴结转移之间则无显著性差异(P>0．05)。结论 Fas、FasL的表达失衡与胃癌的发生发展有着密切关系，并与胃癌的分化和免疫逃逸有关。

Abstract: Objective 　To study the expression of Fas、FasL in gastric carcinogenesis and it s possible significance. Methods 　The expression of Fas and FasL were analyzed with immunohistochemist ry SABC method in different gast ric mucosa. Results 　The positive expression rates of Fas were 46. 6 %for gastric cancer tissues, 51. 6 % for paracarcinoma tissues, and 83. 3 % for tissues of 5cm distance from gastric cancer tissue, 85%for gastric mucosa of benign diseases, and 95%for normal gastric mucosa. The positive expression rates of FasL in the above-mentioned tissues were 86. 6%, 81. 6%, 26. 6%, 20% and 10%. The expression of Fas and FasL was correlated with the degree of tumor differentiation (P<0. 05), but has not significant difference for tumor stage and metastases in lymph nodes (P>0. 05) . Conclusion 　The abnormal expression of Fas and FasL maybe relate with the pathogenesis of gastric cancer and is also involved in the degree of differentiation and the immune escape.

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