MMP-2 、MMP-9和TIMP-1的表达与胃癌淋巴结转移及生存时间的关系

Relationship of the Expression of MMP-2 、MMP-9 、TIMP-1 with Lymph Node Metastasis and Survival Time in Gastric Adenocarcinoma

摘要: 目的研究胃癌细胞MMP-2、MMP-9和TIMP-1的表达与淋巴结转移及生存时间的关系。方法用免疫组织化学方法检测136例胃腺癌组织微阵列中MMP-2、MMP-9和TIMP-1的表达。结果 MMP-9在淋巴结有转移病例中阳性率为76％，与淋巴结转移程度相关(P=0．0228)；N分期和胃癌病人术后生存时间相关(P<0．0001)。结论胃癌细胞中MMP-9阳性可作为预测胃癌淋巴结转移程度的分子标志物，N分期是预测胃癌病人术后生存时间的病理学指标。

Abstract: Objective 　To study the expression of MMP-2, MMP-9 and TIMP-1 in gastric adenocarcinoma. Methods 　Tissue microarray of 136 gastric adenocarcinoma was const ructed by using a microarrayer. The expression of MMP-2, MMP-9 and TIMP-1 was detected on the section of tissue microarray by immuno-histochemistry. Results 　The positive rate of the expression of MMP-9 was 76 % in gastric adenocarcinoma and was related to the magnitude of lymph node metastasis. N staging is related to survival time of gastric adenocarcinoma. Conclusion 　Overexpression of MMP-9 is likely to a marker of lymph node metastasis in gastric adenocarcinoma. N staging is a pathological parameter in survival time of gast ric adenocarcinoma.