以吡喃阿霉素（THP）为主的联合化疗治疗恶性肿瘤51例的临床疗效
The Clinical Efficacy of Pirarublcin Based Combination Chemotherapy for 51 Cases of Various Malignancies
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摘要: 51例恶性肿瘤患者接受以吡喃阿霉素为主的联合化疗?可评价疗效病例44例,完全缓解13例,部分缓解13例,总缓解率59.1%(26/44)?其中恶性淋巴瘤?乳腺癌?非小细胞肺癌和胃癌的缓解率分别为85%(17/20),57.1%(4/7),28.6%(2/7)和33.3%(2/6)?吡喃阿霉素的毒性主要是骨髓抑制,但脱发发生率相对较低,心脏毒性?肝肾功能损害轻微?Abstract: Fifty-one patients with various malignancies were treated with pirarubicin(THP)combination chemotherapy.44 patients were assessable for response and 51patients for toxicity.The results showed that the overall response rate was 59.1%(26/44),with 13 pastients complete response and 13 patients partial response. The response rate of malignant lymphomas, breast cancer, non-small lung cancer and gastric cancer were 85.0% (17/20), 57.1%(4/7),28.6%(2/7),and 33.3%(2/6),respectively. Myelosuppression was main toxicity of pirarubicin, but alopecia was relatively slight and cardiac, liver, renal toxicity were mild.
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Key words:
- Pirarubicin /
- Combination chemotheray /
- Response /
- Toxicity
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