白血病患者红细胞超氧化物歧化酶活性、血清过氧化脂质、维生素E的检测与分析
Red Cell Superoxide Dismutase Serum Lipid Peroxides and Vitamin E Levels in Patients with Leukemia
-
摘要: 本文观察了44例白血病患者红细胞中铜?锌超氧化物歧化酶(RBC·CuZn-SOD)的活性?血清过氧化脂质(LPO)和维生素E(VE)的水平,结果表明RBC·CuZn-SOD活性和LPO水平在白血病患者中显著增高(P值均小于0.01),而VE水平则明显降低(P<0.01)?对其中15例急性白血病(AL)患者进行动态观察,在治疗获完全缓解后,其三者水平恢复到基本正常?反应了白血病患者体内存在着自由基产生和清除的平衡遭到破坏,而治疗缓解后这种失衡状态可望得到部分恢复?Abstract: This article deals with determing the activity of the red cell superoxide dismutase (RBC-Cu.Zn-SOD),serum lipid peroxides (LPO)and vitamin E(VE) in 44cases of leukemia.The results indicated that activity of the RBC-Cu.Zn-SOD and LPO levels were markedly increased (P0.01) in patients of leukemia. Whereas VE concentration was notably decreased(P0.01).Trend observations have been made on 15 cases of acute leukemia.They had remission after treatment and their levels of RBC-Cu.Zn-SOD, LPO and VE went up to basically normal.These changes suggested that there was the disturbance of equilibrium between production and elimination of oxygen free radical in patients with leukemia. It revealed that distubance of equilibrium is partially recovered from treatment.
-
Key words:
- Leukemia Superoxide dismutase Lipid peroxides /
- Vitamin E /
-
-
1 丁克祥，钟水先，姚树人.指血超氧化物歧化醉徽量快速测定法的研究.老年学杂志，1987, 7(2):42. 2 方允中，刘智峰.抗牛CuZn-SOD抗血清与恶性肿瘤病人血中CuZn-SOD的抗原抗体反应.中华医学杂志，1987, 67(6):351. 3 周翔，辛中国，孙国光，等.血清过氧化脂质的测定和意义.白求恩医科大学学报，1985, 11(4):358. 4 Yagik. Assay for Serum Lipid Peroxid Level and itsClinical Significance. New York: Academic press,1982:223. 5 凌虹，唐文淦.血清游离维生素E荧光测定法.临床检验杂志，1990, 8(1):17. 6 莫简主编.医用自由基生物学导论.第1版.北京人民卫生出版社，1989:2. 7 王文杰.超氧自由基与超氧化物歧化酶生理科学进展.1985, 16(3):196. 8 Southorn P A, Powis G, Phil D. Free Radicals in Medicine, I Chemical Nature and Biological Reactions. Mayo Clin Proc, 1988, 63(4):381. 9 Yamanka N. Biochemical end Medical Aspects of Active Uxygen (Hyaichio&Asadak, Eds) University of Tokyo Press Tokyo, 1978:183. 10 孙存普.解放军医学情报，1987, 1(6):254. 11 Saito H. FEBS Lett, 1989, 249(2):253. 12 Bequin Y, Brasseur F, Weber G, et al. Obervations of Serum Trace Elements in Chronic Lymphocytic Leukemia. Cancer, 1987, 60(8):1842.
计量
- 文章访问数: 1013
- HTML全文浏览量: 15
- PDF下载量: 210
下载:
