晚期乳腺癌的内分泌治疗

ENDOCRINE THERAPY FOR ADVANCED BREAST CANCER

摘要: 晚期乳癌的内分泌治疗已有悠久的历史。70年代以来随着雌激素受体测定的开展,使晚期乳癌的内分泌治疗提高到了新的水平,自从发明了雌激素抑制剂Tamoxifen(三苯氧胺)及药物性肾上腺切除Aminoglutethimide(AG),此项治疗又有了新的进展。现将我们81—85年间对53例晚期乳癌的治疗结果报告如下。

Abstract: 53 cases of advanced breast cancer were divided into three groups according to the treatment.There were routine endocrine therapy group (22 cases)，tamosif en group (15 cases) and a minoglutethimide group (16 caser).Estrogen receptors(ER1 and progesteron receptors (PgR) we:e detected in the tumours of all patients by fluoroh- istochemical method, The effective rates of three endocrine therapy groups in ER-post ive patients were 76.9%，77, 8%，81.8%espectively, There were no statistically significant differences among three groups (P>0,05).The effective rates in ER- aegative patients were 0-10%.There were statistically signifticant difference between the effective rates and the levels of estro gen receptors (P < 0,001.The higher the level of the recepror, the higher the effective rate

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