P<sup>53</sup>、P<sup>16</sup>蛋白在卵巢上皮癌中的表达

P⁵³、P¹⁶蛋白在卵巢上皮癌中的表达

摘要: 目的:探索抑癌基因P⁵³、P¹⁶表达与卵巢上皮癌发生的关系。方法:采用免疫组化SP法对27例卵巢上皮癌组织中P⁵³蛋白,P¹⁶蛋白进行检测。结果:卵巢上皮癌P⁵³蛋白阳性表达率为44.44%。P¹⁶蛋白在卵巢上皮癌中表达阳性率为18.52%,P⁵³及P¹⁶表达与病理类型无关。P⁵³蛋白过度表达与临床分期无关。P¹⁶晚期表达阳性率明显减少(P<0.05)。结论:P⁵³、P¹⁶基因表达的改变在卵巢上皮癌发生中起重要的作用。

Abstract: Objectives:To investigate the ralationship between suppressorgene P¹⁶,P⁵³expression and epithelial ovarian cancer. Methods :Immunohistochemistrial staining was used to examine the P¹⁶ protein and P⁵³ protein in 27 cases of epithelial ovarian cancer. Results; The positive staining rate of P⁵³ protein and P¹⁶ protein were 44.44%and 18.52%respect ively.The expression of P¹⁶ protein and P⁵³ protein were no significantly associated with pathological types. The positive staining rate of P¹⁶ protein in late stage was significantly decreasd(P<0.05). Conclusion s:The change of P⁵³ and P¹⁶ expression play important role in epithelial ovarian cancer.