P<sup>53</sup>及nm23在胃癌中的表达及其意义

赵茜; 陈嘉骧; 侯景辉

P⁵³及nm23在胃癌中的表达及其意义

1. 广州市肿瘤医院;2. 广州第六人民医院;3. 中山医科大学肿瘤医院

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出版历程
- 刊出日期: 1999-04-04

P⁵³ and nm23 Significance Expression in Human and Its Clinical Gastric Cancer

Dept of pathol, Guangzhou Cancer Hospital, Guangzhou 510095

摘要

摘要: 应用LSAB免疫组化方法研究P⁵³和nm23表达变化与胃癌生物学行为及淋巴结转移和预后的关系。发现P⁵³及nm23的阳性率分别为61%、60%。P⁵³过表达与淋巴结转移和预后关系密切(P<0.01)。nm23低表达与胃癌侵袭程度、淋巴结转移及预后有明显关系(P<0.01)。P⁵³过表达和nm23低表达在胃癌淋巴结转移及预后中可能起协同作用。提示检测P⁵³蛋白及nm23基因表达状况可作为临床预测胃癌淋巴结转移及预后的一项指标。
- 胃肿瘤 /
- 基因表达 /
- 淋巴结转移 /
- 预后
Abstract: By using LSAB immunohistoehemical methods, the correlation of the expression of P⁵³ and nm23 with the biologic behavior, lymph node metastasis and prognosis in gastric carcinoma was studied. The positive expressions for P⁵³ and nm23 were foul 61%,60%respectively. A significant Correlation was found between P⁵³ overexpression and the lymph node metastasis and prognosis(P<0.01)，A significant correlation was found between nm23 Low-expression and the depth of cancer invasion and the lymph node metastasis and prognosis(P<0.01).The P⁵³ overexpression and nm23 Low-expression to the lym ph nodal metastasis and prognosis might play joint action. It is suggested that detection of P⁵³ protein and nm23 gene expression can be probably used to be afar for in the evaluation of the tendency of lymphtic metastasis and prognosis in the gastric Cancer.
- Gastric neoplasms /
- Gene expression /
- Lymph node metastasis /
- Prognosis

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参考文献(10)

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