P53及nm23在胃癌中的表达及其意义
P53 and nm23 Significance Expression in Human and Its Clinical Gastric Cancer
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摘要: 应用LSAB免疫组化方法研究P53和nm23表达变化与胃癌生物学行为及淋巴结转移和预后的关系。发现P53及nm23的阳性率分别为61%、60%。P53过表达与淋巴结转移和预后关系密切(P<0.01)。nm23低表达与胃癌侵袭程度、淋巴结转移及预后有明显关系(P<0.01)。P53过表达和nm23低表达在胃癌淋巴结转移及预后中可能起协同作用。提示检测P53蛋白及nm23基因表达状况可作为临床预测胃癌淋巴结转移及预后的一项指标。Abstract: By using LSAB immunohistoehemical methods, the correlation of the expression of P53 and nm23 with the biologic behavior, lymph node metastasis and prognosis in gastric carcinoma was studied. The positive expressions for P53 and nm23 were foul 61%,60%respectively. A significant Correlation was found between P53 overexpression and the lymph node metastasis and prognosis(P<0.01)，A significant correlation was found between nm23 Low-expression and the depth of cancer invasion and the lymph node metastasis and prognosis(P<0.01).The P53 overexpression and nm23 Low-expression to the lym ph nodal metastasis and prognosis might play joint action. It is suggested that detection of P53 protein and nm23 gene expression can be probably used to be afar for in the evaluation of the tendency of lymphtic metastasis and prognosis in the gastric Cancer.
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Key words:
- Gastric neoplasms /
- Gene expression /
- Lymph node metastasis /
- Prognosis
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