Abstract: By using LSAB immunohistoehemical methods, the correlation of the expression of P⁵³ and nm23 with the biologic behavior, lymph node metastasis and prognosis in gastric carcinoma was studied. The positive expressions for P⁵³ and nm23 were foul 61%,60%respectively. A significant Correlation was found between P⁵³ overexpression and the lymph node metastasis and prognosis(P<0.01)，A significant correlation was found between nm23 Low-expression and the depth of cancer invasion and the lymph node metastasis and prognosis(P<0.01).The P⁵³ overexpression and nm23 Low-expression to the lym ph nodal metastasis and prognosis might play joint action. It is suggested that detection of P⁵³ protein and nm23 gene expression can be probably used to be afar for in the evaluation of the tendency of lymphtic metastasis and prognosis in the gastric Cancer.