P<sub>53</sub>突变蛋白表达与胃癌远处器官转移有关

P₅₃突变蛋白表达与胃癌远处器官转移有关

摘要: 应用ABC免疫组化染色法，研究P₅₃突变蛋白表达与胃癌周围淋巴结及远处器官转移的关系。结果表明：P₅₃在胃癌中表达率为54.8%（34/62）。P₅₃表达在未发生转移的胃癌中为50%（7/14），在已发生癌周淋巴结转移的胃癌中为56%（27/48），两组无显著性差异（P＞0.05），但在已发生远处器官转移的胃癌中P₅₃表达率为72.7%（8/11），显著高于前两组（P＜0.01）。提示该基因表达与胃癌远处器官转移及不良的预后有关。

Abstract: We have studied the expression of P₅₃ in 62 patients with gastric carcinomas. A standard immunohistochemical technique employing the anti P₅₃ monoclonal antibody (Pab1801) was applied to the routinly fixed and paraffin-embedded material from these tumors. These data suggest that the overexpression of the P₅₃ oncoprotein is an independent marker for poor prognosis in gastric patients.