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非何杰金淋巴瘤276例化疗有/无放疗临床研究

CLINICAL RESEARCH OF CHEMOTHERAPY AND/OR RADIOTHERAPY FOR 276 CASES OF NONIHODGKIN'S LYMPHOMAS

  • 摘要: 1983—1987年,共收治非何杰金淋巴瘤(NHL)化疗有/无放疗276例(单纯化疗95例,化疗加放疗181例)。按国际工作分类,低、中、高度恶性各占4.7%、47%、42.8%,其它5.5%。原发于结内73.2%。本组病例偏晚,ⅢⅣ期占54.4%;B组占全部之1/3。化疗方案以COPP、CHOP、MOPP为主,疗后CR118例(42.8%)、PR93例(33.7%)、CR+PR率76.5%;疗后1、3、5年生存率各为55.1%、29.3%、19.2%。经分析在病理类型、临床分期、A组B组、近期疗效与预后关系密切,治疗在ⅢⅣ期则以足量化+放疗效果较佳。本组毒性反应不严重,无毒性死亡病例。

     

    Abstract: From 1983 to June 1987, 276 cases of non-Hodgkin's lymphomas (NHL) treated by chemotherapy (CT) and/or Radiotherapy (RT) in our hospital. The ratio of male to female was 3.1: 1. The low, intermediate and high grade malignant lymphoma were 4.7%, 47%, 42.8% respectively The primary location in lymph nodes were 202cases (73.2%), out of the lymph nodes were 26.8%. There were 34, 92, 71 and 79 cases in stage Ⅰ, Ⅱ, Ⅲ and Ⅳ respectively, stage Ⅲ to Ⅳ occupy 54,4%, There were 98 cases at B group. On treatment, only combined CT 97 cases, CT+RT 179 cases, the regime of CT were COPP (CTX. VCR. PCZ PDN) CHOP (CTX ADM VCR PDN) MOPP (HN2 VCR PCZ PDN). After treatment, the CR+PR rate were reached to 76.5% (CR 42.8% PR 33.7%) and the one year survival of the whole group was 152 cases (55.1%), two years 106 cases (38.4%), three years 54 cases (29.3%), four years 23 cases (17.8%) five years 10 cases (19.2%), Among of 276 cases, the prognosis of NHL were related to the type of pathology, the stage of clinic, the A or B groups, the rate of CR+PR etc.

     

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