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交链孢酚单甲醚对人淋巴细胞增殖反应的影响

李忠, 刘桂亭, 钱玉珍, 宫亚欧, 郑智敏, 王秀林, 甄应中

李忠, 刘桂亭, 钱玉珍, 宫亚欧, 郑智敏, 王秀林, 甄应中. 交链孢酚单甲醚对人淋巴细胞增殖反应的影响[J]. 肿瘤防治研究, 1991, 18(3): 154-156.
引用本文: 李忠, 刘桂亭, 钱玉珍, 宫亚欧, 郑智敏, 王秀林, 甄应中. 交链孢酚单甲醚对人淋巴细胞增殖反应的影响[J]. 肿瘤防治研究, 1991, 18(3): 154-156.
Li Zhong et, al, . EFFECT OF AME ON PROLIFERATIVE RESPONSE IN HUMAN LYMPHOCYTES[J]. Cancer Research on Prevention and Treatment, 1991, 18(3): 154-156.
Citation: Li Zhong et, al, . EFFECT OF AME ON PROLIFERATIVE RESPONSE IN HUMAN LYMPHOCYTES[J]. Cancer Research on Prevention and Treatment, 1991, 18(3): 154-156.

交链孢酚单甲醚对人淋巴细胞增殖反应的影响

EFFECT OF AME ON PROLIFERATIVE RESPONSE IN HUMAN LYMPHOCYTES

  • 摘要: 本实验运用PHA诱导的淋巴细胞增殖3H—TdR掺入法,对食管癌高发区河南省林县粮食中分离的优势污染菌互隔交链孢霉(亦称链格孢菌)的毒素之一——交链孢酚单甲醚(AME)的免疫抑制作用进行了研究。实验结果表明:AME能明显抑制淋巴细胞对3H—TdR的摄取,在浓度为25、50、75和100μg/ml,其抑制率分别是76.9%、89.2%、91.3%和94.9%,与对照组相比有显著性意义(P<0.01),且存在一定的剂量—效应关系。结果提示AME可能抑制细胞免疫功能。

     

    Abstract: In this paper, we investigated the suppressive effect of AME (alternariol monomethyl ether) on proliferative response in human lymphocytes by use of PHA-induced lymphocyte proliferation SH-TdR incorporation method. The results showed: AME had a significant inhibitory effect on SH-TdR incorporation into lymphocytes. As the concentration of AME was 25ug/ml, 50ug/ml, 75ug/ml and 100μg/ml, its suppressive ratio was 76.9%, 89.2%, 91.3% and 94.9% respectively. The effect of AME was significantly different from control (P0.01), and had does-dependent fashion (Y=12.13-0.10X,r=-0.927, P0.05, alone). This result suggests that AME could inhibit cellular immune and affect the AME-induced carcinogenesis.

     

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出版历程
  • 刊出日期:  1991-09-04

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