Abstract: 12 cases of MFH were reported here. It has 1. 3 percent of primary tumor of bone and 4. 7 percent of primary malignant tumor in the same period. This tumor occurs principally in the extremities. The tumor was easy to be misdiagnosed as osteosarcoma and fibrosarcoma of bone under clinic and X-rayed condition. Microscopically, the tumor comprises of fibroblast, histocyte with pleomorphic giant cells and clamped foamy cells and lymphocytes. I:stochemically, AAt was 100 percent positive. Lyso was 50 percent positive. It was suggested AAT and Lyso were important signs of MFH. This helped us to differentiate with osteosarcoma and fibrosarcoma of bone. superstructurally, It was suggested that MFH was derived from multipotential orignal mesenchymal cells.