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胃癌高发区土地岔乡居民幽门螺旋菌感染的研究

Helicobacter Pylor infection in residents in district with high incidence of gastric Carcinoma in north shaanxi

  • 摘要: 本文对我室于1990年8月在陕北胃癌高发区土地岔乡进行胃癌普查中的325例自然人群胃粘膜活检标本作了幽门螺旋菌(HP)检测的研究.结果显示:该乡居民HP检出率较高(66.77%),并以50~59岁年龄组为高;HP检出部位以胃窦部为多(65.54%);HP检出率随慢性胃炎病变的进展而增高(慢性浅表性胃炎为64.35%;慢性萎缩性胃炎为79.31%;慢性胃炎伴肠化生为82.05%,伴异型增生为86.67%;慢性活动性胃炎为94.79%).这些特征都与本地区胃癌的发生特征相一致.从而提示,胃癌高发区居民HP感染应视为与胃癌发生相关的致病因素,亦为影响慢性胃炎发生发展的一种重要致病因素.

     

    Abstract: HP test was done on 325 gastric mucosal biopies taken from POpulation of Tu ac Cha, oneof the regions with high incidence of gastric carcinoma in North Shaanai, in August, 1990. Theresults show that the HP positive rate was high (66. 77%), and was highest in the cases aged 5059. The part of gastric infected most commen was antral (65. 54%). The mpitive rate increasedas gastritis proceeded: it was 64. 35% in chronic superficial gastritis, 79. 31% in chronic atrophicgastritis,82. 05 % in chronic gastritis complicated by intestinal metaplasfa, 86' 67 K in chronic gastritis with displasia, and 94. 79% in chronic aCtive gastritis. All the characters above were accordant with that of incidence of gastric cardsoma in the recon. The authors suggest that the HP infection, in regions with high incidence of gastric carcinoma, be regarded as one'of the Pathogeulcfactors correlated to gastric carcinoma, and also be one Of the important pathogenic factors to theincidence and progress of chronic gastritis'.

     

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