膀胱移行细胞癌Langerhans细胞的研究

A study of Langerbans cells in transitional cell carcinoma of bladder

摘要: 用S(100)单克隆抗体对49例各级膀胱移行细胞癌中的Langerhans细胞(LC)进行ABC免疫组化染色,并与15例正常膀胱粘膜比较,同时与组织学分级对比分析.结果表明:移行细胞癌各级LC较正常粘膜组明显为高(P<0.01).Ⅰ、Ⅱ级分别与Ⅲ级比较LC密度有极显著性差异(P<0.01),Ⅰ、Ⅱ级间比较LC密度无差异(P>0.05).结果提示:LC参与机体抗移行细胞癌免疫反应,其数量变化可能和该肿瘤的生物学行为有关.

Abstract: Quantitative assessment of Langerhans cells (LC)were performed by ABC immunohistochemical method in specimens of transitional cell carcinoma of bladder (TCC, n= 49) and normal transitionalcell mucosa (NTM, n=15), the histological grade, followup were analysed.The mean density ofLC (cells/HPF) was significantly higher in TCC (Ⅰ=12. 87; Ⅱ =13. 00;Ⅲ=6. 44) than thosein NTM (3. 16) (P0. 01). There is a significant difference between grade, and grade 1, andsame was found between grade., and grade Ⅰ (P0. 01). There was no significant difference between grade Ⅰ and Ⅱ (P0. 05). A significant difference of survival in TCC was found betweenLC high index (8/HPF) and low index (8/HPF) (P0. 025). The results suggest that LC wasdirectly involved in host immune reaction against tumor,and LC detedion may had a implant valueto determine the prognosis of TCC.