唾液酸在消化道恶性肿瘤中的动态变化

The dyhamlc change of static acid In malignant carcinoma of digestive tract

摘要: 本文观察了77例消化道恶性肿瘤治疗前后血清SA值的动态变化.治疗前SA平均值为91.15±29.24mg/dL,明显高于正常值(P<0.01).根据病情轻重显示,术后补充治疗者SA含量<非手术治疗者<非手术治疗伴远处转移者(P<0.05,<0.04).SA阳性者治疗效果较阴性者差,并且SA含量越高,预后越差.本组中55例有治疗评价意义,总有效率为47.22%,SA值阴性的有效率为68.5%,阳性者仅有38.5%,两者相比有显著性差异(P<0.05).疗效达CR或PR时,SA含量较前明显下降,平均值由85.90±25.39降至73.94±28.43(P<0.01),治疗无效时,平均值由101.96±34.85升至115.72±10.10(P<0.01).以上结果提示动态观察SA对判断消化道恶性肿瘤患者病灶有无远处转移,病程转归及预有一定的临床价值.

Abstract: Sialic acid (SA) is a kind of important Component of glacoprotein and glucolipide in the cellmembrane of eukaryotes. The result showed that the dynamic observation of SA has some clinicalValue in judging the existeuce or nonexisteuce of long distance metastasis and the climical course ofmalingrant carcixone of digestive traet.