口服补钙对食管癌前疾患是否有影响──双盲干预试验研究

李珊珊; 裘宋良; 杨观瑞; 赵立群; 郭花芹; 张聚真; 孙豫; 杨中枢

口服补钙对食管癌前疾患是否有影响──双盲干预试验研究

1. 河南省医学科学研究所;2. 美国新泽西州立大学药学院生化研究室

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出版历程
- 刊出日期: 1994-08-04

Whether does Oral Calcium Supplementation Treat Esophageal Precancerous Lesion——A Randomized Double Blind Intervention Trial

Li Shanshan¹,

Institute of Henan Medical Sciences, Zhengzhou

摘要

摘要: 本文对食管癌高发区辉县居民的癌前疾患进行了随机双盲钙干预治疗研究。服药一年后，不论是钙剂（服碳酸钙）治疗组，还是对照组，食管上皮基底细胞增生及炎症状况均有改善，包括内镜、组织学及放射自显影三项指标，两组统计学上未见区别（P>0.05），治疗后的血钙水平两组亦无差异（P>0.05）。由此可见，口服补钙不能对食管癌起到预防作用，对食管癌癌前疾患治疗无效。
- 癌前疾患 /
- 食管 /
- 钙
Abstract: A randomized double blind intervention treating esophageal precancerous lesions with calcium was carried out in the populations of Huixian County Henen province，a high risk area for esopgaheal cancer. After one year, whether the calcium supplemetation group or the placebo group,the basal cell hyperplasia and esophagitis were improved,including endoscopy,histology and H-TdR radiography. It appeared not variance statisticaly between the calcium group and the placebo group (P>0.05). The blood calcium levels of subjects in the calcium and the placebo groups after intervention trial were not variance (P>0.05). Therefure, it is uncertain whether oral calcium supplementation protect from esophageal cancer.

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参考文献(8)

1. Vau Rensburg SJ.Epildemiologic and dietary evidence for a apecific nutritional predisposition to esophageal cancer.JNCI,1981,67:243.

2. Yang CR,Qiu SL.Endoscopic surveys in high-risk and lowrisk populations for esophageal cancer in China vrith epedal reference to precursors of esophageal cancer.Endoscopy,1987,19:91.

3. Qiu SL,Yang GR.Precursor leaiom of esophageal cancer in high risk populations in Henan province,China.Cancer,1988,62:1551.

4. 刘鼎新.放射自显影技术.科学出版杜,1986,30.

5S acks PG,Parses SM,Price JC,et al. In vitro modulation of differentiation by calcium in organ cultures of human and marine epithelial tissue.In Vitro,1985,21:99.

6. Buset M,Lipkin M,Winawer S,et al.Inhibitian of human colonic epithelial cell proliferation in vivo and in vitro by calciym.Cancer Res,1986,46:5426.

7. Newmark HL,Wargovich MJ,Bruce WR.Colon cancer and dietary fat,phosphate,and calcium:A hypothesis.JNCI,1984,72:1323.

8. 张禀真,裘宋良,杨观瑞.食管癌高低发区人群血清钙含量初探.河南肿瘤学杂志,1992,1:29.