辅助化疗对提高胃癌根治术后远期疗效的临床研究
Adjuvant chemotherapy can improve the late result of radical operation in patients with gastric cancer
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摘要: 我们将235例胃癌根治术病例随机分为两组,根治术后加辅助化疗的综合组(112例)和单纯根治术组(123例),研究辅助化疗的临床意义,总的5年生存率综合组为51.8%,明显高于单纯根治术组的30.9%(p<0.01)。其中Ⅱ期胃癌5年生存率综合组与单纯根治术组相比,为70.7%:41.3%,差异有非常显著意义(p<0.01);Ⅲ期胃癌为48.7%:26.8%,差异亦有显著意义(p<0.05);而Ⅰ、Ⅳ期胃癌两组间差异无显著意义(p>0.05)。本研究结果表明,辅助化疗对提高各期胃癌根治术后远期疗效的作用不同,并分析了其原因。Abstract: In order to study the clinical significance of adjuvant chemotherapy,We randomly divided 235 patients who have received radical operation for gastric cancer into two groups.The combination group consisted of 112 cases who were given adjuvant chemotherapy after the operation,While 123 cases in operative group received radical opertion only.The aggregate 5-year survival rate of the combination group(51.8%) is significantly higher than that of the operative group(30.9%)(p<0.0l).Correalting the disease stages with 5-year survivalrate,stage Ⅱ with combination therapygives significantly higher survival rate than simple radical operation(70.7% VS 41.3%)(p<0.01).Stage Ⅲ with combination therapy is also significantly different from simple radical operation(48.7%VS 26.8%)(p<0.05).While for stage I and stage IV no spch significant difference was observed(p>0.05).Our results indicate that postoperative adjuvant chemotherapy can to various degrees improve late result of radical resection of different stages of gastric cancer.
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