乳腺癌ER、PR与DAKO-M1关系的初步探讨
An initial investigation of the expression of ER,PR and DAKO-M1 in breast carcinomas
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摘要: 应用亲和酶标组化标记法和免疫组化ABC法,测定106例乳腺癌组织中ER、PR和DAKO-M1水平。其阳性率分别为83%、81.1%和80.2%。在88例ER阴性乳腺癌中,PR阳性76例,而18例ER阴性乳腺癌中,PR阳性10例。79.2%乳腺癌ER和PR表达一致(p<0.05)。在98例ER和/或PR阳性乳腺癌中,84例DAKO-M1阳性;而8例ER和PR阴性乳腺癌中,7例DAKO-M1阴性。85.7%乳腺癌ER和/或PR和DAKO-M1表达一致(p<0.05)。ER、PR和DAKO-M1阳性率均随组织学分级增高而减低,其在癌组织学分级表达中均有显著意义(p<0.01-0.001)。结果提示,乳腺癌ER、PR和DAKO-M1水平,均可作为对乳腺癌患者治疗方案决策、判断其分化程度和预测预后的参考指标。Abstract: The expression of ER,PR and DAKO-M1 in 106 breast carcinomas were examined by both affinitive histochemical and ABC technique.The positive rates of ER,PR and DAKO-M1 were 83%,81.1% and 80.2% respectively.76 cases of the 88 ER-positive breast carcinomas were PR-positive and 10 cases of 18 ER-positive ones were PR-positive.We found that the expression of ER were in accordance with PR(p<0.05) in 79.2% of the breast carcinomas.As to the expression of DAKO-M1,84 were M1-positive in 98 ER-and/or PR-positive breast carcinomas,and 7 were M1-negative in 8 ER-and PR-negative ones.There for the expression of ER and/or PR were in accordance with M1((p<0.05).The positive rates of ER,PR,and DAKO-M1,whose expression showed remarkable significance((p<0.Ol～0.001),reduced with the increase of hitological differentiation.Thus the level of ER,PR and DAKO-M1 can serve as a reference and may be beneficial to the treatment of patients.
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Key words:
- Breast carcinoma /
- Estrogen receptor(ER) /
- DAKO-M1 /
- Progestin receptor(PR) /
- Immunohitochemistry
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