胃癌组织中肥大细胞与C-erbB-2癌基因蛋白

Mast cell and C-erbB-2 oncoproteins in the tissues or gastric cacinoma

摘要: 用俾士麦棕法和免疫组织化学方法检测了57例胃癌组织中肥大细胞(MC)和C-erbB-2癌基因蛋白。结果表明:(1)MC计数与胃癌的分化程度和转移有关, 高、中分化腺癌高于低分化腺癌和未分化癌(P＞0.05), 无转移者高于有转移者(P＞0.05); (2)C-erbB-2癌基因蛋白阳性表达与胃癌的分化程度和转移无关(P＞0.05); (3)C-erbB-2癌基因蛋白阳性表达与MC计数有关, MC高计组, C-erbB-2癌基因蛋白阳性表达低于MC低计组(P＞0.05)。
- 胃癌 /
- 癌基因 /
- 肥大细胞 /
- 俾士麦棕 /
- 免疫组织化学
Abstract: Bismark brown staining method and immunohistochemical method were used respectively for the observation of mast-cell (MC) and C-erbB-2 oncoproteins in 57 cases of gastric carcinoma. The results showed that:(1)MC counts were related to the differentiation and metastasis of gastric cancer, in the high and moderate differentiation tumors, MC counts were higher than in the low and undifferentiated ones (P＜0.05) and in the metastatictumours they were lower than in the nonmetastatic ones (P＜0.05). (2) C-erbB-2 oncoproteins were not related to the differentiation and metastasis of gastric cancer (P＜0.05).(3) The positive expression of C-erbB-2 oncoproteins were related to MC counts of gastric cancer, high MC count groups were inferior to low MC ones (P＜0.05).
- Gastric cancer /
- Oucoproteins /
- Mast cell /
- Bismark brown /
- Immunohistochemistry

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