Abstract: Thirty cases of primary Carcinoma of livevr are treated with combination immunotherapy ofTNF and IFNr with chemotherapy regimen of LD-FAM. TNF is injected into the tumor. IFNr in-to the muscles. of these Cases, 25 Cases are male. 5 female. AFP of 22 Cases is positive(+).the other negative(一). The analysis of the resultsare; CRB, PR12, NC7, PD3, Countins for 27%、40%、23%、1000 respectively. The total remission rate(CR-PR)is 67% Gererally speaking,the recent effectis Satisfying.