大剂量卡铂并自体骨髓移植治疗小细胞肺癌
High Dose Carboplatin Therapy with Autologous Bone MarrowTrasplantation for Small Cell Lung Cancer
-
摘要: 采用大剂量卡铂并自休骨髓移植（ABMT)治疗5例小细胞肺癌(SCLC)患者，其中男性4例.女性I例，年龄19~55岁，发病到开始ABMT时间3~14个月.5例中4例己接受过不同方案的常规诱导化疗，1例手术切除肺主体病灶.开始大荆童化疗时3例部分缓解(PR)，另2例对常规治疗无明显反应，卡铂荆蚤为560~1375mg/m2.大剂量化疗后4例完全缓解(CR), 1例无明显变化，CR持续时间1. 5~18个月.Abstract: The efficacy of high dose carboplatin therapy with auotologous bone marrow transplantation(ABMT)was studied in five patients with extensive small cell lung cance (SCLC). Among of them, 4 males and 1 female, the average.age was 40. 6 years (range, 19 to 55 years), the median durationfrom dignosis to ABMT was approximately 8. 6 months (range, 3 to 14 months). Four patients hadreceived prior induction chemotherapy and one patient received the surgical therapy. At the begin-ing of high dose therapy, 3 patients had achived partial remission (PR) and other patients had notresponded to routine chemotherapy. The dose of carboplatin ranged from 560 to 1375 mg/mZ. Atthe end of high dose carboplatin therapy with ABMT, there were 4 complete remission (CR) andone case was not changed. The duration of CR ranged from 1. 5 to 18 months
-
-
1 徐昌文，等.肺癌.第二版，上海科技出版社，1993, 221 2 Albain KS, et al. Determinants of improved in small cell lung cancer: An analysis of the 2580 patients southwest oncology group data base. J clip Oncol, 1990, 8:1563 3 Gatgemeier u, et al. Phase I studies with carboplatin in non-small cell lung cancer. Seminars in Oncol, 1990, 17 (1，supl)，25一31 4 Karamer BS, et al. Randomiged phase I evaluation of iproplatin and carboplatin in lung cancer. A Southeast- ern cancer study group trial. Am J Clin Oncol, 1988, 11 :643一645 5 Littlewood T J, et al. Hight dose etoposide with autolo- gous bone marrow transplantation as initial treatment. Eur J Respir Ihs, 1986, 68，370一374 6 Farha P, et al. Hight-dose chemotherapy and autolo- gous bone marrow transplantation for the treatment of small cell lung cancer. Cancer, 1983, 52，1351一1355 7 Bhuchar VK, et al. High-dose cisplain for lung cancer. Cancer Teat Rep, 1982, 66，375一376 8 Spitger G, et al.High-dose intensification therapy withautologous bine marrow suport for limited small-cellbronchogenic carcinoma.J Clin Oncol, 19864:4~13 9 Elias AD,et al.A phase I study of high-dose ifosfamideand esculating doses of carboplatin withautologous bone marrow support. J clin Oncol, 1991, 9 (3) 320 一327 : 10 Stewart P, et al. Intensive chemoraditherapy with au- tologous marrow trans-plantation for small cell carci- noma of lung. Cancer Treat Rep, 1983, 67 (12) 1055~1059 11 Spizer G, et al. High-dose intensification therapy with autologous bone marrow support for Linmited small call bronchogenic ca"cinoma. J Clin Oncol, 1986, 4 (1):4~13 12 Postmus PE, et al. High-dose cyclophasphamide and high-dose Vp-16一213 for recurrent of referactory small cell lung cancers A phase I study. Eur J Cance Clin Oncol, 1985; 21 (12):1467一1470 13 Smith IE, et al. High-dose cyclophosphamide with au- tologous bone marrow resecue after conventional chemotherapy in the treatment of small cell lung carci- noma. Cancer Chemother Pharmacol, 1985, 14 (1): 120一124 14 高和.大剂量化疗并自体骨位移植治疗小细胞肺癌国外医学呼吸系统分册，1992. 12 (4):172~174
计量
- 文章访问数: 1158
- HTML全文浏览量: 30
- PDF下载量: 207
下载:
