胃癌组织溶菌酶、α<sub>1</sub>抗胰蛋白酶及α<sub>1</sub>抗凝乳蛋白酶的免疫组化研究

胃癌组织溶菌酶、α₁抗胰蛋白酶及α₁抗凝乳蛋白酶的免疫组化研究

摘要: 本文对45例胃癌手术标本进行了LZM, AAT及ACT的免疫组化定位观察。结果发现胃癌细胞具有一定合成LZM, AAT及ACT的能力，LZM阳性率的高低与胃癌的分化程度及淋巴结转移密切相关(P<0. OS)，分化程度较好,粘液分泌亢进以及临床呈良性经过的胃癌LZM, AAT及ACT阳性率有增高的趋势。提示LZM, AAT及ACT可用于临床判断恶性度，估价预后的潜在价值。

Abstract: Abstract The gastric tissues were taken from 45 patients with carcinoma of stomach during operation to study the immunohistochemical localization of LZM, AATand ACT. It was found that the cancer cells could synthesize LZM,AAT and ACT to some extent. The detected amount of LZM had a positive correlation with the degree of differentiation and metastasis rate of lymph gland (P0. 05). In gastric carcinoma with more complete differentiation, a strong secretion of mucus and a benigh clinical course, LZM, AAT, and ACT tended to enhance. These results suggest that LZM, AAT, and ACT may have a potential value in estimation of malignant degree and prediction of prognosis.