平阳霉素致死1例并文献复习
THE REPORT OF ONE CASE DIED OF BLEOMYCINUM AND THE LITERATURE REVIEWS
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摘要: 本文报道了一例平阳霉素致死性反应，复习了近十年国内有关文献，分析了平阳霉素的主要三种类型致死性反应-高热、休克、肺炎的临床表现及发病因素和机理，总结出临床使用平阳霉素的注意事项：(1)过敏体质及自身免疫性疾病的病人慎用；(2)非何杰金氏病淋巴瘤病人慎用，中线部位非何病人应尽量避免使用；(3)老年人及肺功能不全者慎用；(4)尽量不对门诊病人使用；(5)抢救中及时进行抗过敏、抗休克治疗；(6)预防性用药以防止或减轻副作用发生。Abstract: This paper reported one patient died of the lethal reaction of bleomycinum(BLM)and reviewed the domestic papers on the side-effects of BLM in the last 10 years.The three clinical manifestations of the reaction,i.e.the high fever,the allergic shock and the pneumotitis, and the pathogenisis were analyzed.In addition,the notices of using BLM were summed up:(1)For the following patients the using of BLM must be cautious:the patients with non-Hodgkin'lymphoma(NHL);the patients with allergic constitution or autoimmune disease;the atged patients and the patients with poor lung-function;(2)For the out-patients and the patients with meddleline-organ NHL,the using of it must be avoided.(3)In case of emergency, the antiallergic and/ or anti-shock managements must be taken immediately.(4)Some medicines can be used to provent or alliviate the side-effects.
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Key words:
- Bleomycinum /
- side-effect
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