Abstract: This paper dealt with the treatment of 74 cases of metastatic bone cancer with Bonefos and /or ¹⁵³Sm-EDTMP intraradiation. 21 cases treated with Bonefos and 26 cases treated with ¹⁵³Sm-EDTMP.the total remission rates of the bone pain were respectively 85. 7% and 80. 8%, and the to-tal effective rates of the bone lesion were respectively 9. 5% and 19. 2 % . 31 cases treated with the combination 13onefos with ¹⁵³Sm-EDTh1P， the two rates before mentioned were respectively 93. 5 % and 45. 2% which was signi-ficantly better than the above results (Ｐ＜0. 05). The side effects were ruse. These results showed that Bonefos plus ¹⁵³Sm-EDTWP are the effective and safe therapy,may be the better treatment of choice against metastaitc multiple bone carcinoma.