恶性肿瘤患者骨质改变的研究

Study on the changes of bone mineral content in patients with malignancy

摘要: 本文测量了50例恶性肿瘤患者桡骨超远端骨矿物质含量及骨密度。骨密度平均值为0.362±0.071.50例患者中有40例骨密度降低（占80%）.本文按与疾病年龄组相配的同性别正常人骨密度的均值-2SD作为骨密度降低。即恶性肿瘤患者骨质减少的诊断标准。恶性肿瘤患者骨密度与正常对照组比较。差异有显着意义（P<0.05）.并且，骨密度降低程度与病程密切相关（P<0.05）.上述结果提示：恶性肿瘤患者常有骨质减少，骨密度降低是其特异性、敏感性指标。
- 恶性肿瘤 /
- 骨质改变
Abstract: We measured the super-extremity bone mineral content and bone mineral density (BMD) of ra-dius in 50 patients with malignancy. BMD was mean 0. 362±0. 071g/cm². 40 patients (80% )had low BhfD. The authors presumed that BMD in the healthy subjects of same sex and age group minus 2SD was the diagnostic criteria of the bone mineral reduction in patients with malignancy. BMD in patients with malignancy was significantly lower than that in the healthy subjects (Ｐ＜0.05)·A close correlation was found between the reduction of BMD and the disease duration. The results in-dicates that most patients with malignancy have reduction of BMD. The reduction of BMD is the pe-culiar and sensitive index of the loss of bone mass.
- Malignancy tumor /
- The changes of bone mineral content

[1]	佐藤斡二.肿疡性高カルシウム血症亡种疡性低リシ血症性骨软化症.クリニカ，1989,16（9）：(571)51
[2]	Miyauchi A, et al. Hemangiopericytoma-induced osteo-malacia: Tumor transplantation in Nude Mice causes hypophosphatemia and tumor extracts inhibit venal 20-hydroxyvitamin D I-hydroxylase activity. J Clin En-dornol Metab, 1988. 67 (1):46
[3]	丁佳芝.骨质疏松症的防治及其研究方向.临床内科杂志，1991，8 (2):44
[4]	Yamamoto I. et al. Circulating I, 20-Dihydroxyvitamin D concentrations in patients with renal cell carcinoma-associated hypercalcemia are ravely suppressed. J Clin Endocrind Metab. 1987. 64 (1);170
[5]	Yoshimoto K, et al. Ectopic production of parathyroid hormone by small cell lung cancer in a patient with hy-percalcemia. J Clin Endocrinol Metab, 1989, 68 (5)， 976
[6]	Sato K, et al. Production of interleukin-I a and a parathyroid hormone-like factor by a sguamos cell car-cinoma of the esophagus (GC. GI) derived from a pa-bent with hypercalcemia. J Clin Endocrinol Metab,1988. 67 (3):592