大、小鼠摄入AFB<sub>1</sub>和羧乙基锗倍半氧化物体内超氧化物歧化酶变化研究

大、小鼠摄入AFB₁和羧乙基锗倍半氧化物体内超氧化物歧化酶变化研究

摘要: 本实验通过观察摄入AFB1及Ge-132后Wistar大鼠和昆明小鼠体内SOD活力的变化，进一步了解AFB1代谢途径和Ge-132与自由基的关系。实验表明，摄入AFB1的SOD活力受到抑制，而摄入Ge-132后SOD活力得到提高，且一次性摄入AFB1后SOD活力最终得到恢复，其中大鼠对AFB1敏感性相对较大。

Abstract: In order to investigate AFB,metabolic pathway in vivo and relationship between Ge-132 and the free radical,the SOD activity in Wistar rats and Kunming maces which had been intaken AFB₁ and Ge-132 before and after were determined.The results showed that the changing tendency of SOD in rats and maces was similar.AFB₁could signficantly reduce the SOD activity in red blood cell,serum and liver tissue.The SOD activity both in rats and mites was stimulated after intaken Ge-132.Inhibitory of the SOD activity by single injection AFB₁ graduated away at last.Wistar rats were more sensitive to AFB₁ than Kunming mites.