大蒜、大蒜绿茶合剂对MNNG诱发实验性胃癌及癌前病变PBL微核率的影响

Changes of micronuclei frequence of peripheral blood lymphocytes on MNNG-induced experimental gastric carcinoma and precancerous lesion by garlic and garlic-green tea mixture

摘要: 本文研究大蒜、大蒜绿茶合剂对MNNG诱发大鼠胃癌及癌前病变过程中PBL微核率的影响。结果显示，MNNG组（MG）MNF在10月与16月时无明显差异，但较对照组（CG）始终显着增高（P<0.001）,胃癌及癌前病变均高于CG（P<0.001）,癌前病变明显低于胃癌（P<0.001）,预防组（PG）、治疗1（TGⅠ）与Ⅱ组（TGⅡ）皆低于MG（P<0.001）,PG在16月较10月时显着降低（P<0.001）,与TGⅠ无明显区别，而TGⅡ较PG10月时差异明显（P<0.005）,但与PG16月时和TGⅡ无差异。证明MNNG的致突变、致癌变性可持续作用，大蒜、绿茶具有明显的抗突变、抗癌变效果，微核先于胃癌出现于癌前病变，从而检测PBL微核可作为胃癌危险和早期的新标志。

Abstract: The effect of garlic and garlic-green tea mixture for micronculei frequence (MNF) of peripheral blood lymphcytes(PBL)on gastric carcinoma(GC) and pre cancerous lesion(PL) in Wistar rats induced by N-methyl-N-nitro一N'一nitrosoguani-dine (MNNG) is studied.The results show,that MNF of MNNG group (MG) by the 10th month and 16th month is similar,of MG,GC and PL is Niger remarkably than control group(CG) (P<0.001),respectively,of PL is lower than GC (P<0.001),of prevention group (PG),treatment groupI(TGI) and II(TGII) decrease,the differance with MG is significant (P<0.01),PG by the 16th month is lower than 10th month